Croscarmellose Sodium Superdisintegrant yeMapiritsi Emishonga | Inokurumidza Kuzvimba, Inoshandiswa Zvakaderera 0.5-5% | USP/EP/JP Inoenderana

Croscarmellose Sodium yedu imhando yepamusoro-soro ye superdisintegrant yakagadzirirwa kushandiswa mukurapa kwakasimba kunosanganisira mapiritsi, makapisiri, uye granules. I sodium carboxymethylcellulose ine mukati memuviri isinganyungudike mumvura asi inokurumidza kuzvimba kusvika pahuwandu hwayo hwepakutanga hwakapetwa ka4-8 kana yakabatana nemvura.Maumbirwo aya akasiyana ane fibrous anopa kugona kwakanaka kwekubvisa mvura uye kushanda zvakanaka kwe capillary, zvichikonzera kuparara kwemapiritsi uye kuwedzera kunyungudika kwemishonga.Inoenderana neUSP-NF, EP, JP, uye ChP pharmacopoeias ine CDE registration F20209990136. Mashandisirwo akajairika: 0.5-5.0% w/w (2% yekudzvanya zvakananga, 3% yekunyorova kwemvura)Yakakodzera kudzvanywa zvakananga, kunyorova (mukati kana kunze kwegranular), kudzvanywa kweroller, uye ma capsule formulations.

Taura nesu

Ruzivo rweChigadzirwa

Mishonga yeCroscarmellose Sodium (CCS)

Pfupiso yeChigadzirwa

Croscarmellose Sodium i sodium carboxymethylcellulose inosanganiswa mukati, yakagadzirirwa kushandiswa sechinhu chinonyanya kushandiswa mumishonga.Kusiyana nezvinhu zvinopatsanurwa zvechinyakare, inopa hunhu hwakanaka hwekupatsanurwa pahuwandu hushoma, zvichiita kuti mapiritsi aparare nekukurumidza uye mishonga inyungudike zvakanyanya kuti ive nani kuwanikwa kwemishonga..

Kuzivikanwa Kwechigadzirwa:

Zita reKemikari:Sodium yeCroscarmellose
Nhamba yeCAS:74811-65-7
Nhamba yekunyoresa yeCDE:F20209990136
Kutevedzera Mutemo wePharmacopoeia:ChP, USP-NF, EP, JP, BP
Nhamba yeEC:629-739-2
Mazwi akafanana:Carboxymethylcellulose ine muchinjikwa Sodium, CCNa, Sodium Croscarmellose, E468

Zvinhu Zvikuru & Mabhenefiti

1. Nzira Yepamusoro Yokuparadzana

Kuparara kwezviito zviviri:Inosanganisa kushanda kwe capillary (kukwenya) nekuzvimba nekukurumidza
Inowedzera kusvika4-8 kakapetwa huwandu hwayo hwepakutangakana yabatwa nemvura
Maumbirwo efiber anopa kugona kwakanaka kwekunwa mvura
Inogadzira kuwedzera kwemuchina kunopwanya mapiritsi nekukurumidza

2. Kushandiswa Kwakaderera - Kushanda Kwakanyanya

Inoshanda pahuwandu hwakaderera se0.5-5.0% w/w
Mashandisirwo akajairika: 2% yekudzvanya zvakananga, 3% yekunyorova kwegranulation
Mhinduro inoshanda pakugadzira fomura

3. Kuchinjika kweKugadzira

Yakakodzera maitiro ese epiritsi: kudzvanywa zvakananga, kunyorova kwemvura, kukwesha kweroller
Mu granulation yakanyorova, inogona kushandiswa mukati me granularly, extra-granularly, kana yakakamurwa pakati pezvikamu zvese zviri zviviri
Inoenderana nemafomura e capsule (kushandiswa kwe10-25%)

4. Hunhu Hwakanaka Hwemuviri

Chitarisiko:Hupfu hunobva pachena kusvika pahuchena, hunoyerera zvakasununguka
Dhigirii rekutsiva:0.60 – 0.85
Vhoriyamu Yekugadzirisa:10.0 – 30.0 ml
pH (1% mhinduro):5.0 – 7.0
Kurasikirwa Nekuomesa:≤10.0%
Zvasara paKubatidza:14.0% – 28.0%
Zvinhu Zvinonyunguduka Mumvura:≤10.0%
Simbi Dzinorema:≤10 ppm

5. Kuenderana kweAPI uye Kugadzikana

Zvinoita hereisina peroxides- inovimbisa kugadzikana kuri nani kwemaAPI anonzwa oxidation
Hapana mhedzisiro yakaipa pakuoma kwepiritsi kana kupfava kwaro
Kushanda kwekuparara kunoramba kwakafanana nekufamba kwenguva
Hazvina GMO, hazvina allergy