Carboxymethylcellulose Calcium (CMC-Ca) Superdisintegrant | Kukwanisa Kuzvimba Kwakanyanya Kwekupararira Kwemapiritsi Nekukurumidza | USP/EP/ChP Inoenderana

Carboxymethylcellulose Calcium yedu (Carmellose Calcium, CMC-Ca) mushonga unoshanda zvakanaka semushonga unobvisa tsvina, unosunga, uye unosanganisa mushonga unonwiwa nemuromo.Imunyu wecalcium we carboxymethylcellulose, unoonekwa seupfu huchena kusvika huchena husinganyunguduke mumvura asi hunokurumidza kuzvimba kusvika pahuwandu hwahwo hwepakutanga kana hukabata mvura.. Nzira iyi yakasiyana yekuzvimba inoita kuti mapiritsi aputsike nekukurumidza uye mushonga unyungudike zvakanyanya. Zvakanakira zvikuru zvinosanganisira: kusava nesodium yakawanda (yakakodzera varwere vane mwoyo neropa uye vane sodium shoma), kudzvanywa kwakanyanya, uye kuenderana nemaitiro ekudzvanywa zvakananga uye ekugadzira granulation yakanyorova Inoenderana neUSP-NF, EP, JP, uye ChP pharmacopoeias ine CDE registration F20230000328. Kushandiswa kwakajairika: 0.5-15% w/w.

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Ruzivo rweChigadzirwa

Carboxymethylcellulose yemhando yemishonga Calcium (Carmellose Calcium, CMC-Ca)

Pfupiso yeChigadzirwa

Carboxymethylcellulose Calcium imunyu wecalcium we polycarboxymethyl ether ye celluloseImushonga unoshanda nemishonga yakawanda unoshandiswa zvakanyanya semushonga unobvisa tsvina, unosunga, uye unonyungudutsa mumhando dzakasimba dzemushonga dzinosanganisira mapiritsi nemakapisi.Kusiyana nesodium, munyu wecalcium une mukana wekugadzira sodium isina sodium, zvichiita kuti ive yakakodzera varwere vane chirwere chemwoyo uye vane sodium shoma..

Kuzivikanwa Kwechigadzirwa:

Zita reKemikari:Carboxymethylcellulose Calcium / Carmelose Calcium
Nhamba yeCAS:9050-04-8
Nhamba yekunyoresa yeCDE:F20230000328
Kutevedzera Mutemo wePharmacopoeia:ChP, USP-NF, EP, JP
Mazwi akafanana:Calcium carboxymethylcellulose, Calcium CMC, CMC-Ca, Carmelose Calcium
VAMWE:UTY7PDF93L
Chitarisiko:Upfu hwakachena kusvika kuchena-yero kana huchena hwakasiyana, husinganyatsooneki mushure mekuomeswa
Kunyunguduka:Hazvinyungudike mumvura, acetone, doro, uye toluene; zvinozvimba mumvura zvichiita kuti pave nechinhu chinonyunguduka

Zvinhu Zvikuru & Mabhenefiti

1. Nzira Yepamusoro Yokuparadzana

Mvura hainyungudike asi inokurumidza kuzvimba kusvikakakawanda vhoriyamu yayo yepakutangakana wasangana nemvura inoyerera
Inogadzira kumanikidzwa kwemuchina kunopwanya mapiritsi nekukurumidza
Inovimbisa kuparara nekukurumidza uye kwakakwana kwekuwedzera kunyungudika kwemishonga
Inoshanda zvakanaka kunyangwe mumapiritsi akaomarara apo mamwe ma disintegrants angasashande zvakanaka

2. Chinhu Chinobatsira Pakushanda Kwakawanda

Kusava neMumwe:Basa guru rekubviswa kwepiritsi pahuwandu hwe0.5-15%
Bhainda:Chinosunga chinoshanda mukuita kwegranulation yakanyorova
Musanganiswa/Muzadzisi:Inogona kushanda semushonga wepiritsi
Rubatsiro rweKumiswa:Inoshandiswa sechinosimbisa kumiswa kwemushonga mukubika nekubika pamusoro pemvura

3. Kubatsira Kusina Sodium

Haina sodium - yakakodzera mishonga yemwoyo nevarwere vane mazinga e sodium akaderera
Inogadzirisa zviri kukura zvinodiwa nemutemo uye nevarwere zvemafomula ane sodium shoma
Inosangana nemaitiro ekugadzira akachena uye ane hanya nehutano

4. Kuenderana Kwakanaka kweAPI

Inoshanda zvakanyanya kunemishonga yecephalosporin, ine hunhu hwakaratidzwa hwekuvandudza kuputsika
Chimiro chakanaka che chelating chinobatsira mamwe makirasi eAPI
Inoshanda nezvinhu zvakasiyana-siyana zvinosanganisira: Pioglitazone HCl, Aminophylline, Berberine HCl, Milnacipran HCl, Cefixime, Nicorandil, nezvimwe zvakawanda

5. Hunhu Hwakanaka Hwemuviri